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Benign Prostatic Hyperplasia: Drug Therapy

Benign Prostatic Hyperplasia - Drug TherapyThrough the last years it has become more evident that benign prostatic hyperplasia (BHP), despite its non-malignant nature, is a progressing disease. There are several choices for the treatment of this condition – drug treatment (Drugs-med.com can provide info about medications helping to relieve its symptoms), minimally invasive therapy and surgery. Which one to choose depends on several factors such as the stage of the disease and severity of the symptoms, patient’s age and concomitant diseases of other body systems.
With the lapse of time, if left untreated, BHP progresses, causes worsening of the urination problems (frequent or urgent urination, nocturia, weak stream, etc.), reduces the quality of patient’s life as well as increases the risk of urinary retention and need for surgery. Here are 4 main options for the drug therapy of benign prostatic hyperplasia:
5-alpha reductase inhibitors. They work by reducing the activity of the 5-alpha reductase enzyme that contributes to the production of the dihydrotestosterone hormone. By doing so, they lower the levels of dihydrotestosterone in the prostate gland, which causes slowing down the growth of prostatic tissue, decreases prostate volume and relieves BPH symptoms. This type of medications is also used for the hair loss treatment.
Alpha-blockers. They work by relaxing certain muscles in the bladder neck, urethra and prostate and thus making it easier to pass urine. Although these medications are good at relieving BHP symptoms, they do not stop the enlargement of the prostate.
Phosphodiesterase-5 inhibitors. PDE-5 inhibitors are originally approved for the treatment of impotence also known as erectile dysfunction; however, they have been reported to significantly improve the symptoms of benign prostatic hyperplasia. Phosphodiesterase-5 inhibitors should not be used in combination with alpha-blockers, since it can cause life-threatening side effects.
Combination therapy. Some patients have the best results when taking both 5-alpha reductase inhibitors and alpha-blockers. The use of both types of medications can be better at easing the symptoms of BHP.

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